Epi-LASIK is also a variant of PRK that, instead, combines elements of LASEK and LASIK. Epi-LASIK is essentially the same procedure as LASEK, but the epithelial "flap" is created using a special modification of the microkeratome blades generally used to make the (deeper) LASIK flap.

The advantage of the Epi-LASIK over LASEK is that no alcohol is used to create the epithelial sheet. This procedure has been shown to result in more rapid recovery and improved comfort when compared to PRK or LASEK.

However, for the same reasons that Dr. Kieval has abandoned the use of microkeratome blades for LASIK, Epi-LASIK possesses increased risk that is obviated by simply performing PRK.